IDE2

Activin/BMP/TGF-β pathway activator
概要
Inducer of definitive endoderm 2 (IDE2) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.). At EC₅₀ = 223nM, SOX17 expression was induced in mouse ES cells.

DIFFERENTIATION
· Induces definitive endoderm from mouse or human ES cells in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.).
Alternative Names
Not applicable
Cell Type
Endoderm, PSC-Derived, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Epithelial Cell Biology, Stem Cell Biology
CAS Number
1136466-93-7
Chemical Formula
C₁₂H₂₀N₂O₃
Molecular Weight
240.3 g/mol
Purity
≥ 98%
Pathway
Activin/Nodal/TGFβ
技术资料
Document Type 产品名称 Catalog # Lot # 语言
Product Information Sheet IDE2 72522, 72524 All English
Safety Data Sheet IDE2 72522, 72524 All English
数据及文献
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