Dibutyryl-cAMP
cAMP pathway activator; Activates cAMP-dependent protein kinases
概要
Dibutyryl-cAMP is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP-dependent protein kinases (Schwede et al.). This product is supplied as the sodium salt of the molecule.
DIFFERENTIATION
· Suppresses experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone towards the demyelinated plaques (Khezri et al.).
· Induces intrinsic axon growth in peripheral and central nervous systems, and morphological differentiation of astrocytes (Knott et al.; Imamura & Ozawa).
· Stimulates neurite outgrowth in PC12 cells (Maruoka et al.).
DIFFERENTIATION
· Suppresses experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone towards the demyelinated plaques (Khezri et al.).
· Induces intrinsic axon growth in peripheral and central nervous systems, and morphological differentiation of astrocytes (Knott et al.; Imamura & Ozawa).
· Stimulates neurite outgrowth in PC12 cells (Maruoka et al.).
Alternative Names
Bucladesine; DC 2797
Cell Type
Astrocytes, Neural Cells, PSC-Derived, Neurons
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Expansion
Area of Interest
Disease Modeling, Neuroscience
CAS Number
16980-89-5
Chemical Formula
C₁₈H₂₃N₅O₈P · Na
Molecular Weight
491.4 g/mol
Purity
≥ 95%
Pathway
cAMP
Target
cAMP-Dependent Kinase
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Dibutyryl-cAMP (Sodium Salt) | 73882, 73884, 73886, 100-0244 | All | English |
| Safety Data Sheet | Dibutyryl-cAMP (Sodium Salt) | 73882, 73884, 73886 | All | English |
| Safety Data Sheet | Dibutyryl-cAMP (Sodium Salt) | 100-0244 | All | English |
数据及文献