Compound E
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
概要
Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).
DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Alternative Names
γ-secretase inhibitor XXI
Cell Type
Brain Tumor Stem Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Maintenance
Area of Interest
Neuroscience
CAS Number
209986-17-4
Chemical Formula
C₂₇H₂₄F₂N₄O₃
"Molecular Weight
490.5 g/mol
Purity
≥ 98%
Pathway
Notch
Target
γ-Secretase
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Compound E | 73952, 73954 | All | English |
| Safety Data Sheet | Compound E | 73952, 73954 | All | English |
数据及文献