Bafilomycin A1

Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).


MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).

CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).