BMS 493

BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).


DIFFERENTIATION
· Affects development of bronchial tubule formation in mice (Chazaud et al.).

· Inhibits activation of immature dendritic cells (Geissmann et al.).

CANCER RESEARCH

· Inhibits differentiation of leukemic blasts (Kamashev et al.).