3-Methyladenine
PI3K/AKT pathway inhibitor
概要
3-Methyladenine has been reported to inhibit autophagy (Seglen & Gordon) by blocking autophagosome formation via the persistent inhibition of class I and transient inhibition of class III phosphoinositide 3-kinase (PI3K; Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
Alternative Names
3-MA; NSC 66389
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Autophagy, Cancer Research, Metabolism
CAS Number
5142-23-4
Chemical Formula
C₆H₇N₅
Molecular Weight
149.2 g/mol
Purity
≥ 95%
Pathway
PI3K/AKT
Target
PI3K
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | 3-Methyladenine | 74222, 74224 | All | English |
| Special Protocol | 3-Methyladenine | 74222 | All | English |
| Safety Data Sheet | 3-Methyladenine | 74222, 74224 | All | English |
数据及文献