SAHA
Epigenetic modifier; Inhibits HDAC1 and HDAC3
概要
SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs). This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).
CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).
· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
Alternative Names
Suberoylanilide hydroxamic acid;
Vorinostat
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Cancer Research, Disease Modeling, Stem Cell Biology
CAS Number
149647-78-9
Chemical Formula
C₁₄H₂₀N
Molecular Weight
264.3 g/mol
Purity
≥ 98%
Pathway
Epigenetic
Target
HDAC
技术资料
Document Type | 产品名称 | Catalog # | Lot # | 语言 |
---|---|---|---|---|
Product Information Sheet | SAHA | 73902, 73904 | All | English |
Safety Data Sheet | SAHA | 73902, 73904 | All | English |
数据及文献