RSC-133
Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
概要
Reprogramming stimulating compound (RSC)-133 is an indole derivative that specifically inhibits DNA methyltransferase DNMT1 (Lee et al.).
REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).
MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).
MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
Alternative Names
Not applicable
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
1418131-46-0
Chemical Formula
C₁₈H₁₅N₃O₂
Molecular Weight
305.3 g/mol
Purity
≥ 95%
Pathway
Epigenetic
Target
DNMT
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | RSC-133 | 73392 | All | English |
| Safety Data Sheet | RSC-133 | 73392 | All | English |
数据及文献
Publications (1)
Angewandte Chemie (International ed. in English) 2012
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
Abstract
Abstract
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).