Quercetin

Quercetin inhibits phosphoinositide 3-kinase isoforms (beta: IC50 = 5.4 µM; gamma: IC50 = 2.4 µM; delta: IC50 = 3.0 µM) and SRC kinases but only shows slight inhibitory activity against serine/threonine kinases ERK1/2 and p38 alpha, as well as protein kinase C (Navarro-Nunez et al.).

REPROGRAMMING
· Stimulates glycolytic metabolism and promotes reprogramming of somatic cells (Zhang et al.).
· Enhances reprogramming of human primary somatic cells to induced pluripotent stem cells (Zhu et al.).

CANCER RESEARCH
· Induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation (Triantafyllou et al.).
· Promotes apoptosis of glioblastoma cells when used together with temozolomide (Sang et al.).
· Reduces tumorigenicity of pancreatic cancer cells (Fan et al.).