Human Recombinant NOV

Neuroblastoma overexpressed gene protein (NOV) is a member of the CCN (CYR61/CTGF/NOV) family. NOV contains four structural domains: a non-functional N-terminal insulin-like growth factor-binding protein (IGFBP) domain, a von Willebrand factor C (vWFC) domain that mediates oligomerization, a thrombospondin type I domain that mediates matrix interactions, and a C-terminal cysteine knot domain that interacts with fibulin 1C, Notch1, and CCN2 (Perbal 2004; Perbal 2006; Perbal et al.; Sakamoto et al.). NOV interacts with integrins αVβ3 and α5β1 to mediate adhesion of endothelial cells, chemotaxis, and angiogenesis (Lin et al.). It also interacts with gap junction protein connexin43 to suppress cell proliferation (Fu et al.). During development, NOV is expressed in multiple tissues including: muscle, endothelium, nervous system, adrenal cortex, and chondrocytes (Martinerie et al.; Perbal 2004; Perbal 2006; Snaith et al.). In cancers expressing the N-terminally truncated version, NOV localizes to the nucleus and promotes proliferation (Planque et al.).