Human Recombinant FGF-17

Fibroblast growth factor 17 (FGF-17) is a heparin binding-member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green et al.). FGF-17 exerts its developmental roles by signaling through FGF receptors 1c, 2c, 3c, and 4 (Olsen et al.; Zhang et al.). FGF-17 also plays a role in organizing and inducing the patterning in the midbrain-hindbrain junction (Cholfin & Rubenstein; Xu et al.). FGF-17 is expressed in the hindgut, parts of the developing skeleton, tail bud, major arteries, and heart (Maruoka et al.).