Human Recombinant Epigen
Epigen
概要
Epigen belongs to the family of epidermal growth factor (EGF) ligands. It is expressed in a variety of tissues, including hepatic, testicular, cardiac, pulmonary, and others. Upon binding to EGF receptor expressed on epithelial cells, epigen triggers mitosis (Schneider & Yarden). The strong mitogenic potential can be explained by the low-affinity binding to EGF receptor, which results in downregulation of receptor ubiquitination. Epigen is also expressed in adenocarcinomas, suggesting a role in oncogenesis (Kochupurakkal et al.).
Subtype
Cytokines
Alternative Names
EPG, EPGN, Epithelial mitogen
Cell Type
Epithelial Cells, Intestinal Cells, Mammary Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology
Molecular Weight
8.1 kDa
Purity
≥ 95%
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant Epigen | 78120, 78120.1 | All | English |
| Safety Data Sheet | Human Recombinant Epigen | 78120, 78120.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant Epigen was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 1 μg/mL. (B) 2 μg of Human Recombinant Epigen was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.