Human Recombinant BMPR-1A Fc

Bone morphogenetic protein receptor type 1A (BMPR-1A) is a type I receptor of the BMP receptor family of transmembrane serine/threonine kinases (Abe; Fischerauer et al.); it is also known as ALK3. BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6. Binding of BMPs to receptor complexes results in phosphorylation of intracellular SMADs, which go on to regulate transcription (Pan et al.). BMP regulation plays a role in proliferation, differentiation, migration, and apoptosis of endothelial and vascular smooth muscle cells (Abe). BMPR-1A deficiency is lethal during gastrulation (Mishina et al.). BMPR-1A is important in chondrogenesis and osteogenesis, along with BMPR-1B (Fischerauer et al.; Jing et al.). This protein contains a C-terminus linker (IEGRMD) to an Fc tag (Human IgG1).