Mouse Recombinant SDF-1 beta (CXCL12)

Stromal cell-derived factor 1 beta (SDF-1 beta) is a splicing variant of CXCL12 and a member of the CXC family of chemokines. SDF-1 beta is constitutively and ubiquitously expressed in most tissues as SDF-1α (89 amino acids) and SDF-1β (93 amino acids) resulting from alternative gene splicing (Janowski). These variants regulate hematopoiesis, lymphocyte homing, B-lineage cell growth, and angiogenesis (De La Luz Sierra et al.). SDF-1 beta binds primarily to CXC receptor 4 (CXCR4, CD184); this receptor has also been shown to serve as a co-receptor for T cell-tropic HIV-1. The SDF-1 beta/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival (Teicher & Fricker). SDF-1 beta is highly expressed in lymph nodes, lung, liver, and bone marrow under homeostatic conditions, and it modulates immune surveillance and development (Sánchez-Martín et al.).