Human Recombinant TNF-beta
Tumor necrosis factor beta
概要
Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).
Subtype
Cytokines
Alternative Names
LT-α, Lymphotoxin-alpha, TNF-beta, TNFSF1, Tumor necrosis factor-β
Cell Type
T Cells
Species
Human
Area of Interest
Immunology
Molecular Weight
18.8 kDa
Purity
≥ 95%
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | Human Recombinant TNF-beta | 78125, 78125.1 | All | English |
| Safety Data Sheet | Human Recombinant TNF-beta | 78125, 78125.1 | All | English |
数据及文献
Data
(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.